Ryan S. Doster, M.D., Ph.D.

• Assistant Professor of Medicine

Ambulatory Care Building
550 South Jackson St, 2nd Floor 550 Clinic
Louisville, KY 40202

502-852-7844 - Academic Office
502-561-8844 - Patient Appointments

Featured Publications

• Lavieri RR, Dubberke ER, McGill SK, Bartelt L, Smith SA, Pandur BK, Phillips SE, Vermillion K, Shirey-Rice J, Pulley J, Xu Y, Lindsell CJ, Zaleski N, Jerome R, Doster RS, Aronoff DM. Walk before you run: Feasibility challenges and lessons learned from the PROCLAIM study, a multicenter randomized controlled trial of misoprostol for prevention of recurrent Clostridioides difficile during COVID-19. Anaerobe. 2023 Apr;80:102699. doi: 10.1016/j.anaerobe.2023.102699. Epub 2023 Jan 23. PMID: 36702174.
• Lu J, Moore RE, Spicer SK, Doster RS, Guevara MA, Francis JD, Noble KN, Rogers LM, Talbert JA, Korir ML, Townsend SD, Aronoff DM, Manning SD, Gaddy JA. Streptococcus agalactiae npx Is Required for Survival in Human Placental Macrophages and Full Virulence in a Model of Ascending Vaginal Infection during Pregnancy. mBio. 2022 Dec 20;13(6):e0287022. doi: 10.1128/mbio.02870-22. Epub 2022 Nov 21. PMID: 36409087; PMCID: PMC9765263.
• Guevara MA, Francis JD, Lu J, Manning SD, Doster RS, Moore RE, Gaddy JA. Streptococcus agalactiae cadD Is Critical for Pathogenesis in the Invertebrate Galleria mellonella Model. ACS Infect Dis. 2022 Dec 9;8(12):2405-2412. doi: 10.1021/acsinfecdis.2c00453. Epub 2022 Nov 29. PMID: 36445344; PMCID: PMC10262471.
• Korir ML, Doster RS, Lu J, Guevara MA, Spicer SK, Moore RE, Francis JD, Rogers LM, Haley KP, Blackman A, Noble KN, Eastman AJ, Williams JA, Damo SM, Boyd KL, Townsend SD, Henrique Serezani C, Aronoff DM, Manning SD, Gaddy JA. Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy. Nat Commun. 2022 Sep 14;13(1):5392. doi: 10.1038/s41467-022-32916-7. PMID: 36104331; PMCID: PMC9474517.
• Iqbal J, Malviya N, Gaddy JA, Zhang C, Seier AJ, Haley KP, Doster RS, Farfán-García AE, Gómez-Duarte OG. Enteroinvasive Escherichia coli O96:H19 is an Emergent Biofilm-Forming Pathogen. J Bacteriol. 2022 Apr 19;204(4):e0056221. doi: 10.1128/jb.00562-21. Epub 2022 Mar 28. PMID: 35343774; PMCID: PMC9017384.
• Nguyen LM, Omage JI, Noble K, McNew KL, Moore DJ, Aronoff DM, Doster RS. Group B streptococcal infection of the genitourinary tract in pregnant and non-pregnant patients with diabetes mellitus: An immunocompromised host or something more? Am J Reprod Immunol. 2021 Dec;86(6):e13501. doi: 10.1111/aji.13501. Epub 2021 Oct 19. PMID: 34570418; PMCID: PMC8668237.
• Lu J, Haley KP, Francis JD, Guevara MA, Doster RS, Craft KM, Moore RE, Chambers SA, Delgado AG, Piazuelo MB, Damo SM, Townsend SD, Gaddy JA. The Innate Immune Glycoprotein Lactoferrin Represses the Helicobacter pylori cag Type IV Secretion System. Chembiochem. 2021 Sep 14;22(18):2783-2790. doi: 10.1002/cbic.202100249. Epub 2021 Jul 8. PMID: 34169626; PMCID: PMC8560179.
• Noble K, Lu J, Guevara MA, Doster RS, Chambers SA, Rogers LM, Moore RE, Spicer SK, Eastman AJ, Francis JD, Manning SD, Rajagopal L, Aronoff DM, Townsend SD, Gaddy JA. Group B Streptococcus cpsE Is Required for Serotype V Capsule Production and Aids in Biofilm Formation and Ascending Infection of the Reproductive Tract during Pregnancy. ACS Infect Dis. 2021 Sep 10;7(9):2686-2696. doi: 10.1021/acsinfecdis.1c00182. Epub 2021 Jun 2. PMID: 34076405; PMCID: PMC8588567.
• Lu J, Francis JD, Guevara MA, Moore RE, Chambers SA, Doster RS, Eastman AJ, Rogers LM, Noble KN, Manning SD, Damo SM, Aronoff DM, Townsend SD, Gaddy JA. Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus. Chembiochem. 2021 Jun 15;22(12):2124-2133. doi: 10.1002/cbic.202100016. Epub 2021 Mar 23. PMID: 33755306; PMCID: PMC8254657.
• Boone RL, Whitehead B, Avery TM, Lu J, Francis JD, Guevara MA, Moore RE, Chambers SA, Doster RS, Manning SD, Townsend SD, Dent L, Marshall D, Gaddy JA, Damo SM. Analysis of virulence phenotypes and antibiotic resistance in clinical strains of Acinetobacter baumannii isolated in Nashville, Tennessee. BMC Microbiol. 2021 Jan 9;21(1):21. doi: 10.1186/s12866-020-02082-1. PMID: 33422000; PMCID: PMC7796680.