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University of Louisville
Department of Chemistry
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| Mailing address:
Department of
Chemistry |
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Frederick A.Luzzio Professor and Vice Chair Organic Chemistry Organic and Medicinal Chemistry
Phone: 502-852-7323 Editorial Board, Letters in Organic Chemistry Associate Editor, Volume 53, Organic Reactions |
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For Related and Useful Links See: |
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| Research Interests | |||||||||||||
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Our current research interests involve the
synthetic organic and medicinal chemistry of experimental cancer
therapeutics. The investigations involve the multistep syntheses of
core pharmacophores, the synthesis of a range of analogues or
metabolites and their effect on and disposition in the biological test
system. These projects are parts of larger projects, conducted in
collaboration with the National Cancer Institute, which focus on the
elucidation of the molecular target or the mode of action of the
compounds as well as the design of analogues possessing a higher
activity or selectivity. Compounds such as TNP-470 and thalidomide are
potent angiogenesis inhibitors and synthetic studies are currently
underway which identify chemical analogues of these compounds as well
as newer and more efficient asymmetric routes to their core
structures. The binding of the ansa macrocycle geldanamycin and the
benzo-fused lactone radicicol to the chaperone heat shock protein
(HSP-90) is of mechanistic importance. The interaction of these types
of compounds with the target HSP-90 leads to inhibition of ATPase
activity and cell cycle disruption, therefore the design and multistep
synthesis of analogues are of interest in our laboratory. |
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| Recent Publications | |||||||||||||
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